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Poster Title: High Concentration Protein Suspensions: A Case Study for Subcutaneous Delivery of Bevacizumab
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Our scientific poster presents a case study on the development of a high concentration protein suspension (400-500 mg/mL) suitable for subcutaneous delivery of therapeutic proteins. Using Bevacizumab as a model system, we explore key considerations for successful product development and design.
Key Learnings:
- Formulation and process design to produce stable spray dried protein particles
- Particle engineering and vehicle selection to maximize the deliverable dose
- Considerations of both protein stability and suspension viscosity in the design of syringable high concentration protein suspensions
Information
About the Author
Erica Schlesinger, PhD
Vice President of Technical Development
Process & Product Development
Erica Schlesinger is Serán’s Vice President of Technical Development. She leads a team that applies scientific rationale and engineering design to problem-solving and pharmaceutical product development. Her research interests include spray-dried biologics (mAb, Phage, Virus, Whole Cells) and controlled-release technologies for long-acting therapeutics.
Erica has over 15 years of experience in pharmaceutical formulation development, process chemistry, and the early-stage development of novel drug delivery systems, and prior to joining Serán, she worked at Genentech, Seattle Genetics, and Regeneron.
Erica holds an undergraduate degree in Chemical Engineering from Cornell University and a Ph.D. in Bioengineering from the Joint Graduate Group in Bioengineering at the University of California San Francisco and UC Berkeley.
About Serán
There's a science to success.™
Serán is a leading science-based CDMO that specializes in a variety of drug delivery and formulation approaches suited to optimizing bioavailability. Serán provides capsules, tablets, multi-particulates, and powder-in-bottle formulations. Our solid dosage forms are engineered for a wide range of formulation approaches such as overcoming solubility challenges and to enable extended-release.